Isaac Smith Hopkins
- Born: 26 May 1808, MD 1
- Marriage (1): Leah A. Graham on 06 Dec 1833 in Somerset Co., MD
- Marriage (2): Melissa Webster in 1863 in MD
- Died: 05 Aug 1888, Wicomico Co., MD
- Buried: Abt 08 Aug 1888, Parsons Cemetery, Salisbury, Wicomico Co., MD
Isaac married Leah A. Graham, daughter of John Graham and Sarah (Sally) Collier, on 06 Dec 1833 in Somerset Co., MD. (Leah A. Graham was born in 1809 in MD 2 and died in 1839-1863 in MD.)
Isaac next married Melissa Webster in 1863 in MD. (Melissa Webster was born on 26 Nov 1824 in MD, died on 18 Nov 1923 in Wicomico Co., MD and was buried about 21 Nov 1923 in Parsons Cemetery, Salisbury, Wicomico Co., MD.)
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